Los líquidos iónicos como prometedores catalizadores en síntesis orgánica: una contribución a la química sostenible
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Date
2017
Journal Title
Journal ISSN
Volume Title
Publisher
Corporación Universitaria Lasallista
Abstract
Introduction. In all chemical processes, a reaction
medium or solvent is required, and such organic
solvents are highly volatile so they are pollutants to the
atmosphere, and new methods, processes and other
solvents are required to minimize the contamination,
and Ionic liquids are proving to be a great alternative
to such problem. Objective. Synthesize imidazole
based ionic liquids with both inorganic and organic
anions and evaluate their potential application as catalysts in important reactions of organic synthesis,
such as asymmetric synthesis, specifically in
asymmetric aldol reacion. Materials and Methods.
Methyl imidazole (99%), 1-bromobutane (97%),
proline (98%), KOH (97%), Ethyl acetate, ethanol,
reagent grade were supplied by Sigma Chemical
Co. It was used the methyl imidazol for the synthesis
of the ionic liquid butyl methyl imidazole bromide,
[Bmim] [Br], and the other ionic liquids were obtained
by metathesis reaction from such ionic liquid, to obtain
the butyl methyl imidazole hydroxy [Bmim] [OH], and
the butyl methyl imidazole prolinate, [Bmim] [Pro].
These ionic liquids were used as catalysts in the
asymmetric aldol reaction. Results. A classical aldol
reaction, p-nitrobenzaldehyde with cyclohexanone
was performed to test the ionic liquids synthesized as
catalysts, and when comparing the results obtained
with conventional methods, advantages were
observed, such as high yields and high selectivity
in less time reaction. Conclusions. Under very mild
reaction conditions, it was possible to reuse up to 6
times the ionic liquid as a reaction catalyst without
losing the mentioned advantages, which makes it a
sustainable system.
Description
Keywords
Corporación Universitaria Lasallista, Líquido iónico, Síntesis orgánica, Reacciones químicas, Catalizadores, Química
Citation
Revista Lasallista de Investigación Vol. 14 N. 2